Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication

	Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication
	Xie, HB; Wang, LG; Fan, CY; Zhang, LC; Adeola, AC; Yin, X; Zeng, ZB; Wang, LX; Zhang, YP
	2021
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:9 页码:3556-3566
摘要	Speciation is a process whereby the evolution of reproductive barriers leads to isolated species. Although many studies have addressed large-effect genetic footprints in the advanced stages of speciation, the genetics of reproductive isolation in nascent stage of speciation remains unclear. Here, we show that pig domestication offers an interesting model for studying the early stages of speciation in great details. Pig breeds have not evolved the large X-effect of hybrid incompatibility commonly observed between good species. Instead, deleterious epistatic interactions among multiple autosomal loci are common. These weak Dobzhansky-Muller incompatibilities confer partial hybrid inviability with sex biases in crosses between European and East Asian domestic pigs. The genomic incompatibility is enriched in pathways for angiogenesis, androgen receptor signaling and immunity, with an observation of many highly differentiated cis-regulatory variants. Our study suggests that partial hybrid inviability caused by pervasive but weak interactions among autosomal loci may be a hallmark of nascent speciation in mammals.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13410
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Xie, HB,Wang, LG,Fan, CY,et al. Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(9):3556-3566.
APA	Xie, HB.,Wang, LG.,Fan, CY.,Zhang, LC.,Adeola, AC.,...&Zhang, YP.(2021).Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication.MOLECULAR BIOLOGY AND EVOLUTION,38(9),3556-3566.
MLA	Xie, HB,et al."Genetic Architecture Underlying Nascent Speciation-The Evolution of Eurasian Pigs under Domestication".MOLECULAR BIOLOGY AND EVOLUTION 38.9(2021):3556-3566.

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2023031545.pdf（4127KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文