Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome

	Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome
	Jagannathan, V; Hitte, C; Kidd, JM; Masterson, P; Murphy, TD; Emery, S; Davis, B; Buckley, RM; Liu, YH; Zhang, XQ; Leeb, T; Zhang, YP; Ostrander, EA; Wang, GD
	2021
发表期刊	GENES
卷号	12 期号:6
摘要	The domestic dog has evolved to be an important biomedical model for studies regarding the genetic basis of disease, morphology and behavior. Genetic studies in the dog have relied on a draft reference genome of a purebred female boxer dog named Tasha initially published in 2005. Derived from a Sanger whole genome shotgun sequencing approach coupled with limited clone-based sequencing, the initial assembly and subsequent updates have served as the predominant resource for canine genetics for 15 years. While the initial assembly produced a good-quality draft, as with all assemblies produced at the time, it contained gaps, assembly errors and missing sequences, particularly in GC-rich regions, which are found at many promoters and in the first exons of protein-coding genes. Here, we present Dog10K_Boxer_Tasha_1.0, an improved chromosome-level highly contiguous genome assembly of Tasha created with long-read technologies that increases sequence contiguity >100-fold, closes >23,000 gaps of the CanFam3.1 reference assembly and improves gene annotation by identifying >1200 new protein-coding transcripts. The assembly and annotation are available at NCBI under the accession GCF_000002285.5.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13547
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Jagannathan, V,Hitte, C,Kidd, JM,et al. Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome[J]. GENES,2021,12(6).
APA	Jagannathan, V.,Hitte, C.,Kidd, JM.,Masterson, P.,Murphy, TD.,...&Wang, GD.(2021).Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome.GENES,12(6).
MLA	Jagannathan, V,et al."Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome".GENES 12.6(2021).

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2023032102.pdf（1562KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文