Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements

	Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements
	Sahlen, P; Liu, YH; Xu, JR; Kubinyi, E; Wang, GD; Savolainen, P
	2021
发表期刊	GENOME BIOLOGY AND EVOLUTION
ISSN	1759-6653
卷号	13 期号:4
摘要	Research on the genetics of domestication most often focuses on the protein-coding exons. However, exons cover only a minor part (1-2%) of the canine genome, whereas functional mutations may be located also in regions beyond the exome, in regulatory regions. Therefore, a large proportion of phenotypical differences between dogs and wolves may remain genetically unexplained. In this study, we identified variants that have high allelic frequency differences (i.e., highly differentiated variants) between wolves and dogs across the canine genome and investigated the potential functionality. We found that the enrichment of highly differentiated variants was substantially higher in promoters than in exons and that such variants were enriched also in enhancers. Several enriched pathways were identified including oxytocin signaling, carbohydrate digestion and absorption, cancer risk, and facial and body features, many of which reflect phenotypes of potential importance during domestication, including phenotypes of the domestication syndrome. The results highlight the importance of regulatory mutations during dog domestication and motivate the functional annotation of the noncoding part of the canine genome.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13550
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Sahlen, P,Liu, YH,Xu, JR,et al. Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements[J]. GENOME BIOLOGY AND EVOLUTION,2021,13(4).
APA	Sahlen, P,Liu, YH,Xu, JR,Kubinyi, E,Wang, GD,&Savolainen, P.(2021).Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements.GENOME BIOLOGY AND EVOLUTION,13(4).
MLA	Sahlen, P,et al."Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements".GENOME BIOLOGY AND EVOLUTION 13.4(2021).

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