Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation

	Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation
	Zeng, L; Liu, HQ; Tu, XL; Ji, CM; Gou, X; Esmailizadeh, A; Wang, S; Wang, MS; Wang, MC; Li, XL; Charati, H; Adeola, AC; Adedokun, RAM; Oladipo, O; Olaogun, SC; Sanke, OJ; Godwin, FM; Ommeh, SC; Agwanda, B; Lichoti, JK; Han, JL; Zheng, HK; Wang, CF; Zhang, YP; Frantz, LAF; Wu, DD
	2021
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	42 期号:4 页码:450-+
摘要	Over the last several hundred years, donkeys have adapted to high-altitude conditions on the Tibetan Plateau. Interestingly, the kiang, a closely related equid species, also inhabits this region. Previous reports have demonstrated the importance of specific genes and adaptive introgression in divergent lineages for adaptation to hypoxic conditions on the Tibetan Plateau. Here, we assessed whether donkeys and kiangs adapted to the Tibetan Plateau via the same or different biological pathways and whether adaptive introgression has occurred. We assembled a de novo genome from a kiang individual and analyzed the genomes of five kiangs and 93 donkeys (including 24 from the Tibetan Plateau). Our analyses suggested the existence of a strong hard selective sweep at the EPAS1 locus in kiangs. In Tibetan donkeys, however, another gene, i.e., EGLN1, was likely involved in their adaptation to high altitude. In addition, admixture analysis found no evidence for interspecific gene flow between kiangs and Tibetan donkeys. Our findings indicate that despite the short evolutionary time scale since the arrival of donkeys on the Tibetan Plateau, as well as the existence of a closely related species already adapted to hypoxia, Tibetan donkeys did not acquire adaptation via admixture but instead evolved adaptations via a different biological pathway.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13564
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Zeng, L,Liu, HQ,Tu, XL,et al. Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation[J]. ZOOLOGICAL RESEARCH,2021,42(4):450-+.
APA	Zeng, L.,Liu, HQ.,Tu, XL.,Ji, CM.,Gou, X.,...&Wu, DD.(2021).Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation.ZOOLOGICAL RESEARCH,42(4),450-+.
MLA	Zeng, L,et al."Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation".ZOOLOGICAL RESEARCH 42.4(2021):450-+.

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