Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection

	Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection
	Xu, T; Guo, Y; Qi, XP
	2019
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	20 期号:9
摘要	Inflammasome activation is essential for host immune responses during pathogenic infection and sterile signals insult, whereas excessive activation is injurious. Thus, inflammasome activation is tightly regulated at multiple layers. Ubiquitination is an important post-translational modification for orchestrating inflammatory immune responses during pathogenic infection, and a major target hijacked by pathogenic bacteria for promoting their survival and proliferation. This review summarizes recent insights into distinct mechanisms of the inflammasome activation and ubiquitination process triggered by bacterial infection. We discuss the complex regulatory of inflammasome activation mediated by ubiquitination machinery during bacterial infection, and provide therapeutic approaches for specifically targeting aberrant inflammasome activation.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13591
专题	科研部门_病原菌感染与宿主免疫机制（齐晓朋）
推荐引用方式 GB/T 7714	Xu, T,Guo, Y,Qi, XP. Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(9).
APA	Xu, T,Guo, Y,&Qi, XP.(2019).Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(9).
MLA	Xu, T,et al."Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.9(2019).

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