| A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells |
| Qi, SG; Quan, LQ; Cui, XY; Li, HM; Zhao, XD; Li, RT
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| 2020
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| 发表期刊 | ONCOLOGY LETTERS
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| ISSN | 1792-1074
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| 卷号 | 19期号:2页码:1384-1392 |
| 摘要 | Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E was investigated, and the results demonstrated that it inhibited the proliferation of GSCs (GSC-3#, GSC-12#, GSC-18#) with the IC50 values of 7.13 +/- 1.41, 13.51 +/- 1.46 and 4.44 +/- 0.22 mu g/ml, respectively. In addition, immunofluorescence cell staining and flow cytometry techniques demonstrated that rupesin E inhibited GSC proliferation and induced apoptosis. Furthermore, rupesin E inhibited the ability of GSC colony formation, indicating its antitumor activity against GSCs in vitro. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13599
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| 专题 | 科研部门_肿瘤干细胞生物学（赵旭东）
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推荐引用方式
GB/T 7714 |
Qi, SG,Quan, LQ,Cui, XY,et al. A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells[J]. ONCOLOGY LETTERS,2020,19(2):1384-1392.
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| APA |
Qi, SG,Quan, LQ,Cui, XY,Li, HM,Zhao, XD,&Li, RT.(2020).A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells.ONCOLOGY LETTERS,19(2),1384-1392.
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| MLA |
Qi, SG,et al."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells".ONCOLOGY LETTERS 19.2(2020):1384-1392.
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