Landscape of genomic imprinting and its functions in the mouse mammary gland

	Landscape of genomic imprinting and its functions in the mouse mammary gland
	Xu, HB; Zhao, LN; Feng, X; Ma, YJ; Chen, W; Zou, L; Yang, Q; Sun, JH; Yu, H; Jiao, BW
	2020
发表期刊	JOURNAL OF MOLECULAR CELL BIOLOGY
ISSN	1674-2788
卷号	12 期号:11 页码:857-869
摘要	Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic imprinting remain limited. In this study, we found that both the number of IGs and their expression levels decreased during development of the mouse mammary gland. IG expression was lineage-specific and related to mammary gland development and lactation. Meta-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell stemness and differentiation, which was confirmed by our functional studies. Accordingly, our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland maturity. Taken together, our findings revealed the importance of IGs in a poorly studied nutrition-related organ, i.e. the mammary gland, thus providing a reference for further studies on genomic imprinting.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13639
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Xu, HB,Zhao, LN,Feng, X,et al. Landscape of genomic imprinting and its functions in the mouse mammary gland[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2020,12(11):857-869.
APA	Xu, HB.,Zhao, LN.,Feng, X.,Ma, YJ.,Chen, W.,...&Jiao, BW.(2020).Landscape of genomic imprinting and its functions in the mouse mammary gland.JOURNAL OF MOLECULAR CELL BIOLOGY,12(11),857-869.
MLA	Xu, HB,et al."Landscape of genomic imprinting and its functions in the mouse mammary gland".JOURNAL OF MOLECULAR CELL BIOLOGY 12.11(2020):857-869.

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2023041207.pdf（3787KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文