Can EGFR be a therapeutic target in breast cancer?

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	Can EGFR be a therapeutic target in breast cancer?
	Li, XY; Zhao, LN; Chen, CS; Nie, JY; Jiao, BW
	2022
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
ISSN	0304-419X
卷号	1877 期号:5
摘要	Epidermal growth factor receptor (EGFR) is highly expressed in certain cancer types and is involved in regulating the biological characteristics of cancer progression, including proliferation, metastasis, and drug resistance. Various medicines targeting EGFR have been developed and approved for several cancer types, such as lung and colon cancer. To date, however, EGFR inhibitors have not achieved satisfactory clinical results in breast cancer, which continues to be the most serious malignant tumor type in females. Therefore, clarifying the underlying mechanisms related to the ineffectiveness of EGFR inhibitors in breast cancer and developing new EGFR-targeted strategies (e.g., combination therapy) remain critical challenges. Various studies have demonstrated aberrant expression and maintenance of EGFR levels in breast cancer. In this review, we summarize the regulatory mechanisms underlying EGFR protein expression in breast cancer cells, including EGFR mutations, amplification, endocytic dysfunction, recycling acceleration, and degradation disorders. We also discuss potential therapeutic strategies that act directly or indirectly on EGFR, including reducing EGFR protein expression, treating the target protein to mediate precise clearance, and inhibiting non-EGFR signaling pathways. This review should provide new therapeutic perspectives for breast cancer patients with high EGFR expression.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13667
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Li, XY,Zhao, LN,Chen, CS,et al. Can EGFR be a therapeutic target in breast cancer?[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,2022,1877(5).
APA	Li, XY,Zhao, LN,Chen, CS,Nie, JY,&Jiao, BW.(2022).Can EGFR be a therapeutic target in breast cancer?.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,1877(5).
MLA	Li, XY,et al."Can EGFR be a therapeutic target in breast cancer?".BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1877.5(2022).

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2023032901.pdf（2868KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文