The roles and regulation of the KLF5 transcription factor in cancers

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	The roles and regulation of the KLF5 transcription factor in cancers
	Luo, Y; Chen, CS
	2021
发表期刊	CANCER SCIENCE
ISSN	1347-9032
卷号	112 期号:6 页码:2097-2117
摘要	Kruppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13669
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Luo, Y,Chen, CS. The roles and regulation of the KLF5 transcription factor in cancers[J]. CANCER SCIENCE,2021,112(6):2097-2117.
APA	Luo, Y,&Chen, CS.(2021).The roles and regulation of the KLF5 transcription factor in cancers.CANCER SCIENCE,112(6),2097-2117.
MLA	Luo, Y,et al."The roles and regulation of the KLF5 transcription factor in cancers".CANCER SCIENCE 112.6(2021):2097-2117.