EphA2: A promising therapeutic target in breast cancer

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	EphA2: A promising therapeutic target in breast cancer
	Zhao, P; Jiang, DW; Huang, YC; Chen, CS
	2021
发表期刊	JOURNAL OF GENETICS AND GENOMICS
ISSN	1673-8527
卷号	48 期号:4 页码:261-267
摘要	Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proliferation, survival, migration, invasion, drug resistance, metastasis, and angiogenesis. As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity, EphA2 has become a promising therapeutic target for breast cancer treatment. Here, we summarize the expression, functions, mechanisms of action, and regulation of EphA2 in breast cancer. We also list the potential therapeutic strategies targeting EphA2. Furthermore, we discuss the future directions of studying EphA2 in breast cancer. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13672
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Zhao, P,Jiang, DW,Huang, YC,et al. EphA2: A promising therapeutic target in breast cancer[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(4):261-267.
APA	Zhao, P,Jiang, DW,Huang, YC,&Chen, CS.(2021).EphA2: A promising therapeutic target in breast cancer.JOURNAL OF GENETICS AND GENOMICS,48(4),261-267.
MLA	Zhao, P,et al."EphA2: A promising therapeutic target in breast cancer".JOURNAL OF GENETICS AND GENOMICS 48.4(2021):261-267.

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