| Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts |
| Yang, JL; Ma, YH; Li, YH; Zhang, YP ; Tian, HC; Huang, YC; Li, Y; Chen, W; Yang, LJ
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| 2019
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| 发表期刊 | ACS OMEGA
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| ISSN | 2470-1343
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| 卷号 | 4期号:23页码:20381-20393 |
| 摘要 | A series of novel trimethoxyphenyl-derived chalcone-benzimidazolium salts were synthesized. The biological properties of the compounds were screened in vitro against five different human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole or 2-methyl-benzimidazole ring as well as the 2-naphthylmethyl, 4-methylbenzyl, or 2-naphthylacyl substituent at position-3 of the benzimidazole ring was important to the cytotoxic activity. Notably, (E)-5,6-dimethy1-3-(naphth alen-2-ylmethyl)-1-(3-(4-(3-(3,4,5-trime thoxyphenyl) a cryloyl) phenoxy)propyl)-1H-benzo [d] imidazol-3-ium bromide (7f) was more selective to HL-60, MCF-7, and SW-480 cell lines with IC50 values 8.0-, 11.1-, and 5.8-fold lower than DDP. Studies of the antitumor mechanism of action showed that compound 7f could induce cell-cycle G1 phase arrest and apoptosis in SMMC-7721 cells. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13952
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| 专题 | 遗传资源与进化国家重点实验室_分子进化与基因组多样性（张亚平）
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推荐引用方式
GB/T 7714 |
Yang, JL,Ma, YH,Li, YH,et al. Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts[J]. ACS OMEGA,2019,4(23):20381-20393.
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| APA |
Yang, JL.,Ma, YH.,Li, YH.,Zhang, YP.,Tian, HC.,...&Yang, LJ.(2019).Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts.ACS OMEGA,4(23),20381-20393.
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| MLA |
Yang, JL,et al."Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts".ACS OMEGA 4.23(2019):20381-20393.
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