| Cordycepin (3 '-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination |
| Jia, Y; Li, HR; Bao, HK; Zhang, DD; Feng, L; Xiao, YH; Zhu, KM; Hou, YY; Luo, SL; Zhang, YP ; Xiao, L; Chen, X; Zhou, JJ; Wang, CM; Wang, G; Yu, HJ; Xiao, CJ; Du, J
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| 2019
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| 发表期刊 | INTERNATIONAL IMMUNOPHARMACOLOGY
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| ISSN | 1567-5769
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| 卷号 | 75期号:X页码:X |
| 摘要 | Multiple sclerosis (MS) is an inflammatory demyelination disease characterized by autoimmune damage to the central nervous system. In this disease, failure of remyelination could cause persistent disability. Cordycepin, also known as 3'-deoxyadenosine, exerts anti-inflammatory, anti-oxidic, anti-apoptotic and neuroprotective effects. The cuprizone (CPZ) model has been widely used to study MS as it mimics some characteristics of demyelination disease. To determine whether cordycepin promotes remyelination and functional recovery after CPZ-induced demyelination, we administered cordycepin to the CPZ-induced demyelination mice. Cordycepin reversed CPZ-induced loss of body weight and rescued motor dysfunction in the model mice. Cordycepin effectively promoted remyelination and enhanced MBP expression in the corpus callosum. Cordycepin also inhibited the CPZ-induced increase in the number of Iba1-positive microglia, GFAP-positive astrocytes and Olig2-positive oligodendroglial precursor cells in the corpus callosum and cerebral cortex. Pro-inflammatory cytokine expression (IL-1 beta and IL-6) was inhibited while anti-inflammatory cytokine IL-4 and neurotrophic factor BDNF release was elevated in the corpus callosum and hippocampus after cordycepin treatment. In addition, we also found that cordycepin ameliorated CPZ-induced body weight loss, motor dysfunction, demyelination, glial cells activation and pro-inflammatory cytokine expression in the corpus callosum and hippocampus. Our results suggest that cordycepin may represent a useful therapeutic agent in demyelination-related diseases via suppression of neuroinflammation. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13953
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| 专题 | 遗传资源与进化国家重点实验室_分子进化与基因组多样性（张亚平）
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推荐引用方式
GB/T 7714 |
Jia, Y,Li, HR,Bao, HK,et al. Cordycepin (3 '-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2019,75(X):X.
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| APA |
Jia, Y.,Li, HR.,Bao, HK.,Zhang, DD.,Feng, L.,...&Du, J.(2019).Cordycepin (3 '-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination.INTERNATIONAL IMMUNOPHARMACOLOGY,75(X),X.
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| MLA |
Jia, Y,et al."Cordycepin (3 '-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination".INTERNATIONAL IMMUNOPHARMACOLOGY 75.X(2019):X.
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