Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau

	Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau
	Peng, MS; Liu, YH; Shen, QK; Zhang, XH; Dong, JJ; Li, JX; Zhao, H; Zhang, H; Zhang, XM; He, YX; Shi, H; Cui, CY; Ouzhuluobu; Wu, TY; Liu, SM; Gonggalanzi; Baimakangzhuo; Bai, CJ; Duojizhuoma; Liu, T; Dai, SS; Murphy, RW; Qi, XB; Dong, GH; Su, B; Zhang, YP
	2023
发表期刊	BMC BIOLOGY
卷号	21 期号:1
摘要	Background Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood. Little is known how Tibetans adapted to milk and dairy products.Results We integrated archeological evidence and genetic analysis to show the picture that the dairy ruminants, together with dogs, were introduced from West Eurasia into the Tibetan Plateau since similar to 3600 years ago. The genetic admixture between the exotic and indigenous dogs enriched the candidate lactase persistence (LP) allele 10974A > G of West Eurasian origin in Tibetan dogs. In vitro experiments demonstrate that - 13838G > A functions as a LP allele in Tibetans. Unlike multiple LP alleles presenting selective signatures in West Eurasians and South Asians, the de novo origin of Tibetan-specific LP allele - 13838G > A with low frequency (similar to 6-7%) and absence of selection corresponds - 13910C > T in pastoralists across eastern Eurasia steppe.Conclusions Results depict a novel scenario of genetic and cultural adaptations to diet and expand current understanding of the establishment of dairy pastoralism in the Tibetan Plateau.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13994
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Peng, MS,Liu, YH,Shen, QK,et al. Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau[J]. BMC BIOLOGY,2023,21(1).
APA	Peng, MS.,Liu, YH.,Shen, QK.,Zhang, XH.,Dong, JJ.,...&Zhang, YP.(2023).Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau.BMC BIOLOGY,21(1).
MLA	Peng, MS,et al."Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau".BMC BIOLOGY 21.1(2023).

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