| Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect GSTCD expression |
| Li, JX; Huang, XZ; Fu, WP; Zhang, XH; Mauki, DH; Zhang, J; Sun, C; Dai, LM; Zhong, L; Yu, L; Zhang, YP
|
| 2023
|
| 发表期刊 | ISCIENCE
 |
| 卷号 | 26期号:8 |
| 摘要 | Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, is influenced by genetic factors. The genetic signal rs10516526 in the glutathione S-transferase C-terminal domain containing (GSTCD) gene is a highly significant and reproducible signal associated with lung function and COPD on chromosome 4q24. In this study, comprehensive bioinformatics analyses and experimental verifications were detailly implemented to explore the regulation mechanism of rs10516526 and GSTCD in COPD. The results suggested that low expression of GSTCD was associated with COPD (p = 0.010). And C-Jun and CREB1 transcription factors were found to be essential for the regulation of GSTCD by rs80245547 and rs72673891. Moreover, rs80245547T and rs72673 891G had a stronger binding ability to these transcription factors, which may promote the allele-specific long-range enhancer-promoter interactions on GSTCD, thus making COPD less susceptible. Our study provides a new insight into the relationship between rs10516526, GSTCD, and COPD. |
| 收录类别 | SCI
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13996
|
| 专题 | 科研部门_分子进化与基因组多样性（张亚平）
|
推荐引用方式
GB/T 7714 |
Li, JX,Huang, XZ,Fu, WP,et al. Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect GSTCD expression[J]. ISCIENCE,2023,26(8).
|
| APA |
Li, JX.,Huang, XZ.,Fu, WP.,Zhang, XH.,Mauki, DH.,...&Zhang, YP.(2023).Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect GSTCD expression.ISCIENCE,26(8).
|
| MLA |
Li, JX,et al."Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect GSTCD expression".ISCIENCE 26.8(2023).
|
修改评论