Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans
	He, YX; Zheng, WS; Guo, YB; Yue, T; Cui, CY; Ouzhuluobu; Zhang, H; Liu, K; Yang, ZH; Wu, TY; Qu, J; Jin, ZB; Yang, J; Lu, F; Qi, XB; Su, B
	2023
发表期刊	ISCIENCE
卷号	26 期号:9
摘要	Tibetans are the ideal population to study genetic adaptation in extreme environments. Here, we performed systematic phenotyping of 11,880 highlanders, covering 133 quantitative traits of 13 organ systems. We provided a comprehensive phenotypic atlas by comparing altitude adaptation and altitude acclimatization. We found the differences between adaptation and acclimatization are quantitative rather than qualitative, with a whole-system blunted effectseen in the adapted Tibetans. We characterized twelve different functional changes between adaptation and acclimatization. More importantly, we established a landscape of adaptive phenotypes of indigenous Tibetans, including 45 newly identified Tibetan adaptation-nominated traits, involving specific changes of Tibetans in internal organ state, metabolism, eye morphology, and skin pigmentation. In addition, we observed a sex-biased pattern between altitude acclimatization and adaptation. The generated atlas of phenotypic landscape provides new insights into understanding of human adaptation to high-altitude environments, and it serves as a valuable blueprint for future medical and physiological studies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14057
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	He, YX,Zheng, WS,Guo, YB,et al. Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans[J]. ISCIENCE,2023,26(9).
APA	He, YX.,Zheng, WS.,Guo, YB.,Yue, T.,Cui, CY.,...&Su, B.(2023).Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans.ISCIENCE,26(9).
MLA	He, YX,et al."Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans".ISCIENCE 26.9(2023).

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