Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude
	He, YX; Guo, YB; Zheng, WS; Yue, T; Zhang, H; Wang, B; Feng, ZY; Cui, CY; Liu, K; Zhou, B; Zeng, XR; Li, LY; Wang, TY; Wang, Y; Zhang, C; Xu, SH; Qi, XB; Su, B
	2023
发表期刊	CURRENT BIOLOGY
ISSN	0960-9822
卷号	33 期号:19 页码:4037+
摘要	The adaptation of Tibetans to high-altitude environments has been studied extensively. However, the direct assessment of evolutionary adaptation, i.e., the reproductive fitness of Tibetans and its genetic basis, remains elusive. Here, we conduct systematic phenotyping and genome-wide association analysis of 2,252 mother-newborn pairs of indigenous Tibetans, covering 12 reproductive traits and 76 maternal physiological traits. Compared with the lowland immigrants living at high altitudes, indigenous Tibetans show better reproductive outcomes, reflected by their lower abortion rate, higher birth weight, and better fetal development. The results of genome-wide association analyses indicate a polygenic adaptation of reproduction in Tibetans, attributed to the genomic backgrounds of both the mothers and the newborns. Furthermore, the EPAS1-edited mice display higher reproductive fitness under chronic hypoxia, mirroring the situation in Tibetans. Collectively, these results shed new light on the phenotypic pattern and the genetic mechanism of human reproductive fitness in extreme environments.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14059
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	He, YX,Guo, YB,Zheng, WS,et al. Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude[J]. CURRENT BIOLOGY,2023,33(19):4037+.
APA	He, YX.,Guo, YB.,Zheng, WS.,Yue, T.,Zhang, H.,...&Su, B.(2023).Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude.CURRENT BIOLOGY,33(19),4037+.
MLA	He, YX,et al."Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude".CURRENT BIOLOGY 33.19(2023):4037+.

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