Hypoxic response patterns in lung tissue: An integrated analysis of comparative physiological and transcriptomic studies from Neodon fuscus and Lasiopodomys brandtii

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	Hypoxic response patterns in lung tissue: An integrated analysis of comparative physiological and transcriptomic studies from Neodon fuscus and Lasiopodomys brandtii
	Li, XJ; Li, MY; Huang, ML; Li, JZ; Huang, S; Wang, BB; Gao, Y; Wang, ZL; Shi, LY
	2023
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
卷号	892
摘要	Oxygen (O2) is essential for the survival and reproduction of most species. However, in recent years, with global cli-mate change and the increasing impact of human activities on the ecosystem, the frequency of extreme environmental events, such as heat waves, cold waves, droughts, and floods, has increased, resulting in dramatic changes in environ-mental oxygen concentration (hypoxic environment, etc.), threatening the survival of animals and pushing them to-ward extreme adaptation. In this context, how organisms, especially those with differences in original habitats, adapt to low oxygen environment is particularly important. In this study, we systematically analyzed hypoxic response patterns in lung tissues of small rodents Neodon fuscus, Lasiopodomys brandtii, and Mus musculus with different experi-ences of natural hypoxia tolerance through laboratory simulation of hypoxia environment, combined with hematolog-ical, histological, and transcriptomic analysis. Our results show that all three species exhibit increased antioxidant defense and damage repair ability to a certain extent under hypoxia, although the specific molecular mechanisms are not the same. L. brandtii showed better damage repair ability than the others, which is likely to be closely related to the intermittent hypoxia environment experienced in the natural environment, and genes such as Glrx5, Prdx2, Col1a1, Lama1, and Eln may play a crucial role in this process. In addition, we found that both N. fuscus and L. brandtii appropriately enhanced oxygen transport in tissues under hypoxic conditions, with a series of functional genes related to hemoglobin synthesis and vascular smooth muscle contraction were significantly up-regulated in both species of voles, such as Actg2, Ptgir, Alas2, Hba, Hbb and Bpgm. Our results, to a certain extent, reveal the differ-ences and similarities of hypoxic response patterns in lung tissues of small rodents with different hypoxic life histories and provide a relatively perfect analytical paradigm for related studies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14099
专题	其他
推荐引用方式 GB/T 7714	Li, XJ,Li, MY,Huang, ML,et al. Hypoxic response patterns in lung tissue: An integrated analysis of comparative physiological and transcriptomic studies from Neodon fuscus and Lasiopodomys brandtii[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,892.
APA	Li, XJ.,Li, MY.,Huang, ML.,Li, JZ.,Huang, S.,...&Shi, LY.(2023).Hypoxic response patterns in lung tissue: An integrated analysis of comparative physiological and transcriptomic studies from Neodon fuscus and Lasiopodomys brandtii.SCIENCE OF THE TOTAL ENVIRONMENT,892.
MLA	Li, XJ,et al."Hypoxic response patterns in lung tissue: An integrated analysis of comparative physiological and transcriptomic studies from Neodon fuscus and Lasiopodomys brandtii".SCIENCE OF THE TOTAL ENVIRONMENT 892(2023).

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