E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS

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	E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS
	Zheng, M; Liu, WJ; Zhang, R; Jiang, DW; Shi, YJ; Wu, YY; Ge, F; Chen, CS
	2024
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	20 期号:7 页码:2686-2697
摘要	Triple -negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Breast cancer stem cells (BCSCs) are believed to play a crucial role in the carcinogenesis, therapy resistance, and metastasis of TNBC. It is well known that inflammation promotes stemness. Several studies have identified breast cancer -associated gene 2 (BCA2) as a potential risk factor for breast cancer incidence and prognosis. However, whether and how BCA2 promotes BCSCs has not been elucidated. Here, we demonstrated that BCA2 specifically promotes lipopolysaccharide (LPS)-induced BCSCs through LPS induced SOX9 expression. BCA2 enhances the interaction between myeloid differentiation primary response protein 88 (MyD88) and Toll -like receptor 4 (TLR4) and inhibits the interaction of MyD88 with deubiquitinase OTUD4 in the LPS-mediated NF- kappa B signaling pathway. And SOX9, an NF- kappa B target gene, mediates BCA2's pro-stemness function in TNBC. Our findings provide new insights into the molecular mechanisms by which BCA2 promotes breast cancer and potential therapeutic targets for the treatment of breast cancer.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14224
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Zheng, M,Liu, WJ,Zhang, R,et al. E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2024,20(7):2686-2697.
APA	Zheng, M.,Liu, WJ.,Zhang, R.,Jiang, DW.,Shi, YJ.,...&Chen, CS.(2024).E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,20(7),2686-2697.
MLA	Zheng, M,et al."E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 20.7(2024):2686-2697.

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