Divergent Evolutionary Rates of Primate Brain Regions as Revealed by Genomics and Transcriptomics

	Divergent Evolutionary Rates of Primate Brain Regions as Revealed by Genomics and Transcriptomics
	Zhuang, XL; Shao, Y; Chen, CY; Zhou, L; Yao, YG; Cooper, DN; Zhang, GJ; Wang, W; Wu, DD
	2024
发表期刊	GENOME BIOLOGY AND EVOLUTION
ISSN	1759-6653
卷号	16 期号:2
摘要	Although the primate brain contains numerous functionally distinct structures that have experienced diverse genetic changes during the course of evolution and development, these changes remain to be explored in detail. Here we utilize two classic metrics from evolutionary biology, the evolutionary rate index (ERI) and the transcriptome age index (TAI), to investigate the evolutionary alterations that have occurred in each area and developmental stage of the primate brain. We observed a higher evolutionary rate for those genes expressed in the non-cortical areas during primate evolution, particularly in human, with the highest rate of evolution being exhibited at brain developmental stages between late infancy and early childhood. Further, the transcriptome age of the non-cortical areas was lower than that of the cerebral cortex, with the youngest age apparent at brain developmental stages between late infancy and early childhood. Our exploration of the evolutionary patterns manifest in each brain area and developmental stage provides important reference points for further research into primate brain evolution.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14233
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Zhuang, XL,Shao, Y,Chen, CY,et al. Divergent Evolutionary Rates of Primate Brain Regions as Revealed by Genomics and Transcriptomics[J]. GENOME BIOLOGY AND EVOLUTION,2024,16(2).
APA	Zhuang, XL.,Shao, Y.,Chen, CY.,Zhou, L.,Yao, YG.,...&Wu, DD.(2024).Divergent Evolutionary Rates of Primate Brain Regions as Revealed by Genomics and Transcriptomics.GENOME BIOLOGY AND EVOLUTION,16(2).
MLA	Zhuang, XL,et al."Divergent Evolutionary Rates of Primate Brain Regions as Revealed by Genomics and Transcriptomics".GENOME BIOLOGY AND EVOLUTION 16.2(2024).

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2024073002.pdf（620KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文