Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases

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	Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases
	Liu, XS; Novak, B; Namendorf, C; Steigenberger, B; Zhang, YY; Turck, CW
	2024
发表期刊	ISCIENCE
ISSN	2589-0042
卷号	27 期号:4
摘要	Protein turnover is an important mechanism to maintain proteostasis. Long-lived proteins (LLPs) are vulnerable to lose their function due to time -accumulated damages. In this study we employed in vivo stable isotope labeling in mice from birth to postnatal day 89. Quantitative proteomics analysis of ten tissues and plasma identified 2113 LLPs, including widespread and tissue -specific ones. Interestingly, a significant percentage of LLPs was detected in plasma, implying a potential link to age -related cardiovascular diseases. LLPs identified in brains were related to neurodegenerative diseases. In addition, the relative quantification of DNA -derived deoxynucleosides from the same tissues provided information about cellular DNA renewal and showed good correlation with LLPs in the brain. The combined data reveal tissue -specific maps of mouse LLPs that may be involved in pathology due to a low renewal rate and an increased risk of damage. Tissue -derived peripheral LLPs hold promise as biomarkers for aging and age -related diseases.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14416
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Liu, XS,Novak, B,Namendorf, C,et al. Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases[J]. ISCIENCE,2024,27(4).
APA	Liu, XS,Novak, B,Namendorf, C,Steigenberger, B,Zhang, YY,&Turck, CW.(2024).Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases.ISCIENCE,27(4).
MLA	Liu, XS,et al."Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases".ISCIENCE 27.4(2024).

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2024073012.pdf（4771KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文