Differences in brain regions of Aβ and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease

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	Differences in brain regions of Aβ and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease
	Wang, NY; Zhao, Z; Wang, XY; Chen, XZ; Jiang, FW; Tan, YH; Chen, WL; Meng, Q
	2024
发表期刊	BIOMOLECULES AND BIOMEDICINE
ISSN	2831-0896
摘要	Distinct brain regions are differentially affected during the various stages of Alzheimer's disease (AD). While the hippocampus and cortex are known to play significant roles, the involvement of the cerebellum has received less attention. Understanding the changes in diverse brain regions is essential to unravel the neuropathological mechanism in early-stage AD. Our research aimed to explore and compare amyloid- l3 (Al3) pathology and gene expression profiles across the hippocampus, cortex, and cerebellum in the early stages of the Amyloid Precursor Protein/Presenilin-1 (APP/PS1) mouse model. By 7 months of age, significant Al3 plaque accumulation was observed in the hippocampus and cortex of APP/PS1 mice, while no such deposits were found in the cerebellum. Gene expression analysis revealed predominant effects on immune response pathways in the hippocampus and cortex. Even in the absence of Al3 deposition, notable gene expression changes were observed in the cerebellum of APP/PS1 mice. Intriguingly, Neuronal PAS Domain protein 4 ( Npas4 ) expression was consistently down- regulated across all brain regions, independent of Al3 plaque presence. Our findings reveal distinct transcriptomic alterations and Al3 pathology in select cerebral regions during the initial phase of AD. Notably, the diminished expression of the Npas4 across three brain regions implies that Npas4 could play a pivotal role in the early pathogenesis of AD.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14438
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Wang, NY,Zhao, Z,Wang, XY,et al. Differences in brain regions of Aβ and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease[J]. BIOMOLECULES AND BIOMEDICINE,2024.
APA	Wang, NY.,Zhao, Z.,Wang, XY.,Chen, XZ.,Jiang, FW.,...&Meng, Q.(2024).Differences in brain regions of Aβ and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease.BIOMOLECULES AND BIOMEDICINE.
MLA	Wang, NY,et al."Differences in brain regions of Aβ and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease".BIOMOLECULES AND BIOMEDICINE (2024).

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