VDGE: a data repository of variation database for gene-edited animals across multiple species

	VDGE: a data repository of variation database for gene-edited animals across multiple species
	Shi, WW; Jin, EH; Fang, L; Sun, YL; Fan, ZJ; Zhu, JW; Liang, CZ; Zhang, YP; Zhang, YQ; Wang, GD; Zhao, WM
	2024
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	53 期号:D1 页码:D1250-D1260
摘要	Gene-edited animals are crucial for addressing fundamental questions in biology and medicine and hold promise for practical applications. In light of the rapid advancement of gene editing technologies over the past decade, a dramatically increased number of gene-edited animals have been generated. Genome editing at off-target sites can, however, introduce genomic variations, potentially leading to unintended functional consequences in these animals. So, there is an urgent need to systematically collect and collate these variations in gene-edited animals to aid data mining and integrative in-depth analyses. However, existing databases are currently insufficient to meet this need. Here, we present the Variation Database of Gene-Edited animals (VDGE, https://ngdc.cncb.ac.cn/vdge), the first open-access repository to present genomic variations and annotations in gene-edited animals, with a particular focus on larger animals such as monkeys. At present, VDGE houses 151 on-target mutations from 210 samples, and 115,710 variations identified from 107 gene-edited and wild-type animal trios through unified and standardized analysis and concurrently provides comprehensive annotation details for each variation, thus facilitating the assessment of their functional consequences and promoting mechanistic studies and practical applications for gene-edited animals. [GRAPHICS]
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14477
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Shi, WW,Jin, EH,Fang, L,et al. VDGE: a data repository of variation database for gene-edited animals across multiple species[J]. NUCLEIC ACIDS RESEARCH,2024,53(D1):D1250-D1260.
APA	Shi, WW.,Jin, EH.,Fang, L.,Sun, YL.,Fan, ZJ.,...&Zhao, WM.(2024).VDGE: a data repository of variation database for gene-edited animals across multiple species.NUCLEIC ACIDS RESEARCH,53(D1),D1250-D1260.
MLA	Shi, WW,et al."VDGE: a data repository of variation database for gene-edited animals across multiple species".NUCLEIC ACIDS RESEARCH 53.D1(2024):D1250-D1260.

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WGD2025040204.pdf（1635KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文