iDog: a multi-omics resource for canids study

	iDog: a multi-omics resource for canids study
	Liu, YH; Wang, YB; Sun, JN; Kong, DM; Zhou, BW; Ding, MT; Meng, YY; Duan, GY; Cui, Y; Fan, ZJ; Zhang, YP; Zhao, WM; Tang, BX
	2024
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	53 期号:D1 页码:D1039-D1046
摘要	iDog (https://ngdc.cncb.ac.cn/idog/) is a comprehensive public resource for domestic dogs ( Canis lupus familiaris) and wild canids, designed to integrate multi-omics data and provide data services for the worldwide canine research community. Notably, iDog 2.0 features a 15-fold increase in genomic samples, including 29.55 million single nucleotide polymorphisms (SNPs) and 16.54 million insertions / deletions (InDels) from 1929 modern samples and 29.09 million SNPs from 1 1 1 ancient Canis samples. Additionally, 43487 breed-specific SNPs and 530 disease / trait- associated variants have been identified and integrated. The platform also includes data from 141 BioProjects involving gene expression analyses and a single-cell transcriptome module containing data from 105 057 Beagle hippocampus cells. iDog 2.0 also includes an epignome module that evaluates DNA methylation patterns across 547 samples and chromatin accessibility across 87 samples for the analysis of gene expression regulation. Additionally, it provies phenotypic data for 897 dog diseases, 3207 genotype-to-phenotype (G2P) pairs, and 349 dog disease-associated genes, along with two newly constructed ontologies for breed and disease standardization. Finally, 13 new analytical tools have been added. Given these enhancements, the updated iDog 2.0 is an invaluable resource for the global cannie research community.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14491
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Liu, YH,Wang, YB,Sun, JN,et al. iDog: a multi-omics resource for canids study[J]. NUCLEIC ACIDS RESEARCH,2024,53(D1):D1039-D1046.
APA	Liu, YH.,Wang, YB.,Sun, JN.,Kong, DM.,Zhou, BW.,...&Tang, BX.(2024).iDog: a multi-omics resource for canids study.NUCLEIC ACIDS RESEARCH,53(D1),D1039-D1046.
MLA	Liu, YH,et al."iDog: a multi-omics resource for canids study".NUCLEIC ACIDS RESEARCH 53.D1(2024):D1039-D1046.

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ZYP2025040204.pdf（1198KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文