| Repressor elements provide insights into tissue development and phenotypes in pigs |
| Zhang, YD; Guo, C; Liu, H ; Gao, Y; Tan, YJ; Niu, LJ; Wang, LG; Wang, LX; Irwin, DM; Hou, CH; Zhou, ZY; Zhang, YP
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| 2024
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| 发表期刊 | ZOOLOGICAL RESEARCH
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| ISSN | 2095-8137
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| 卷号 | 45期号:6页码:1313-1326 |
| 摘要 | Repressor elements significantly influence economically relevant phenotypes in pigs; however, their precise roles and characteristics are inadequately understood. In the present study, we employed H3K27me3 profiling, assay for transposase-accessible chromatin with highthroughput sequencing (ATAC-seq), and RNA sequencing (RNA-seq) data across six tissues derived from three embryonic layers to identify and map 2 034 super repressor elements (SREs) and 22 223 typical repressor elements (TREs) in the pig genome. Notably, many repressor elements were conserved across mesodermal and ectodermal tissues. SREs exhibited tight regulation of their target genes, affecting a limited number of genes within a specific genomic region with pronounced effects, while TREs exerted broader but weaker regulation over a wider range of target genes. Furthermore, in neuronal tissues, genes regulated by repressor elements started to be repressed during the differentiation of stem cells into progenitor cells. Notably, analysis showed that many repressor elements exhibited cooperative and additive effects on the modulation of KLF4 expression. This research provides the first comprehensive map of pig repressor elements, serving as an essential reference for future studies on repressor elements. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14492
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| 专题 | 科研部门_分子进化与基因组多样性（张亚平）
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推荐引用方式
GB/T 7714 |
Zhang, YD,Guo, C,Liu, H,et al. Repressor elements provide insights into tissue development and phenotypes in pigs[J]. ZOOLOGICAL RESEARCH,2024,45(6):1313-1326.
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| APA |
Zhang, YD.,Guo, C.,Liu, H.,Gao, Y.,Tan, YJ.,...&Zhang, YP.(2024).Repressor elements provide insights into tissue development and phenotypes in pigs.ZOOLOGICAL RESEARCH,45(6),1313-1326.
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| MLA |
Zhang, YD,et al."Repressor elements provide insights into tissue development and phenotypes in pigs".ZOOLOGICAL RESEARCH 45.6(2024):1313-1326.
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