Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression

	Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression
	Li, JN; Wang, NY; Huang, Q; Jiao, CX; Liu, WL; Yang, CX; Tang, X; Mao, RR; Zhou, QX; Ding, YQ; Shan, BC; Xu, L
	2025
发表期刊	ACS CHEMICAL NEUROSCIENCE
ISSN	1948-7193
卷号	16 期号:4 页码:659-672
摘要	Acute ischemic stroke (AIS) is a significant brain disease with a high mortality and disability rate. Additional therapies for AIS are urgently needed, and neuroplasticity mechanisms by agents are expected to be neuroprotective for AIS. As a major active component of Salvia miltiorrhiza, salvianolic acid A (SAA) has shown potential for preventing cardiovascular diseases. However, there is no evidence of the long-term effect of SAA on ischemic injury or its mechanism. Therefore, using rats and mice, we systematically investigated the impact of SAA on AIS from the perspective of neuroprotective and neuroplasticity. Here, we report that SAA induces a long-term depression (LTD)-like process in synapses. This antiexcitotoxicity action supports the SAA effect, including alleviating infarction and promoting blood circulation in photothrombosis and middle cerebral artery occlusion (MCAO) models. Furthermore, repeated positron emission tomography/computed tomography (PET/CT) imaging and behavioral assessments two months after AIS induction reveal that acute treatment of SAA promotes recovery from disrupted whole-brain glucose metabolism and impaired spatial memory. These data suggest that acute treatment of SAA is neuroprotective by improving long-term functional outcomes through a synaptic LTD-like process, providing a promising adjunct to current therapies to enable better recovery for AIS.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14537
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Li, JN,Wang, NY,Huang, Q,et al. Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression[J]. ACS CHEMICAL NEUROSCIENCE,2025,16(4):659-672.
APA	Li, JN.,Wang, NY.,Huang, Q.,Jiao, CX.,Liu, WL.,...&Xu, L.(2025).Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression.ACS CHEMICAL NEUROSCIENCE,16(4),659-672.
MLA	Li, JN,et al."Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression".ACS CHEMICAL NEUROSCIENCE 16.4(2025):659-672.

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