Portrait of WWP1: the current state in human cancer

KIZ OpenIR

	Portrait of WWP1: the current state in human cancer
	Lei, JM; Chen, J; Yu, WW; Wu, Q; Jing, S; Tang, YG; Lin, L; Hu, MC
	2025
发表期刊	FRONT CELL DEV BIOL
ISSN	2296-634X
卷号	12
摘要	WWP1, a member of the C2-WW-HECT E3 ligase family, is an E3 ubiquitin-protein ligase containing WW domains. This enzyme plays a critical role in regulating diverse cellular processes. Its expression is modulated by various factors and non-coding RNAs, resulting in ubiquitination that affects substrate protein degradation. WWP1 demonstrates a dual function, acting predominantly as an oncogene in tumors but occasionally as a tumor suppressor. This review summarizes WWP1's biological roles, therapeutic potential in oncology, upstream regulatory factors, and downstream substrates. It aims to promote research on WWP1's antitumor effects, improve understanding of its role in tumorigenesis, and support the development of targeted therapies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14713
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Lei, JM,Chen, J,Yu, WW,et al. Portrait of WWP1: the current state in human cancer[J]. FRONT CELL DEV BIOL,2025,12.
APA	Lei, JM.,Chen, J.,Yu, WW.,Wu, Q.,Jing, S.,...&Hu, MC.(2025).Portrait of WWP1: the current state in human cancer.FRONT CELL DEV BIOL,12.
MLA	Lei, JM,et al."Portrait of WWP1: the current state in human cancer".FRONT CELL DEV BIOL 12(2025).