Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China

	Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China
	Duan, RF; Yang, HY; Zhai, XW; Yu, J; Lu, C; Yang, WM; Long, TF; Dao, Y; Li, GF; Zhou, YC; Zheng, HY; Zhao, FH; Zheng, YT; Huang, YC
	2025
发表期刊	Sci Rep
ISSN	2045-2322
卷号	15 期号:1
摘要	To evaluate the accuracy and acceptability of self-sampling samples for HPV testing for cervical cancer screening in rural Yunnan of China. In 2022, 3000 women aged 17-69 were recruited and provided self-sampling vaginal samples alongside provider-sampling samples for HPV DNA and E6/E7 mRNA testing, as well as artificial intelligence (AI)-assisted cytology. Women who tested positive for any high-risk HPV DNA or mRNA, or who displayed cytology abnormalities, were recalled for a colposcopy examination and biopsied when necessary. The accuracy of these tests in detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2 +) and CIN3 + was evaluated. The sensitivity of the HPV DNA test for self-sampling was 96.2%, compared to 92.3% for provider-sampling, 73.1% for the mRNA test, and 53.9% for AI-assisted cytology in detecting CIN2 + . The specificity was 83.9% for self-sampling HPV DNA test, 86.4% for provider-sampling HPV DNA test, 91.4% for the mRNA test, and 94.2% for AI-assisted cytology. The area under the curve (AUC) values for these screening methods were 0.90, 0.90, 0.82, and 0.74, respectively. Only 37% of participants preferred the self-sampling model, with lower preference observed among older women, those from rare minority groups, those with lower education levels, and who displayed limited knowledge, attitudes, and practices regarding cervical cancer screening. Self-sampling HPV DNA testing demonstrated comparable clinical accuracy to provider-sampling test and were more accurate than that of mRNA test and AI-assisted cytology. Self-sampling HPV testing offers a promising screening strategy in rural Yunnan China. Applicable health education is urgently needed to improve the acceptability of 'self-sampling' model among the target population.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14809
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Duan, RF,Yang, HY,Zhai, XW,et al. Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China[J]. Sci Rep,2025,15(1).
APA	Duan, RF.,Yang, HY.,Zhai, XW.,Yu, J.,Lu, C.,...&Huang, YC.(2025).Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China.Sci Rep,15(1).
MLA	Duan, RF,et al."Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China".Sci Rep 15.1(2025).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2026070707.pdf（1278KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文