| Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation |
| Ma, X; Zhang, HY; Ni, DX; Tan, JX; Wang, BB; Gao, WC; Zhang, RH; Xiao, WL; Zheng, YT; Zheng, CB
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| 2026
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| 发表期刊 | Biochem. Biophys. Res. Commun.
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| ISSN | 0006-291X
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| 卷号 | 817 |
| 摘要 | Myocardial hypertrophy is a pathological remodeling process characterized by cardiomyocyte enlargement and cardiac dysfunction. Its high prevalence and strong association with heart failure and arrhythmias constitute a major public health burden. Currently, pharmacological options that effectively halt or reverse this condition remain limited. The Jumonji domain-containing protein 3 (JMJD3)-specific inhibitor GSK-J4 has emerged as a potential anti-hypertrophic agent, we used GSK-J4 as a lead compound to design and synthesize a novel derivative. Compound N8, which exhibits potent anti-hypertrophic activity coupled with lower cytotoxicity compared to GSK-J4 and prazosin. In addition, compound N8 serves as a multiorgan protective agent that not only rescues pressure-overload- induced cardiac dysfunction but also prevents consequent injury to the liver and kidneys. Collectively, our data support the further development of novel targeted therapies for pathological cardiac hypertrophy. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14810
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
Ma, X,Zhang, HY,Ni, DX,et al. Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation[J]. Biochem. Biophys. Res. Commun.,2026,817.
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| APA |
Ma, X.,Zhang, HY.,Ni, DX.,Tan, JX.,Wang, BB.,...&Zheng, CB.(2026).Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation.Biochem. Biophys. Res. Commun.,817.
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| MLA |
Ma, X,et al."Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation".Biochem. Biophys. Res. Commun. 817(2026).
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