Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors

KIZ OpenIR > 科研部门 > 转化基因组（李明）

	Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors
	Gao, K; Yang, Y; Sun, XX; Wang, JX; Sun, XQ; Lu, TL; Wang, LF; Li, M; Yue, WH; Liu, HS; Zhang, D; Li, J
	2025
发表期刊	Sci. Adv.
卷号	11 期号:21
摘要	Major depression is a prevalent and devastating psychiatric disorder. However, our understanding of the underlying molecular mechanisms is limited. Here, we found reduced expression of zinc finger protein with Kr & uuml;ppel-associated box and SCAN domains 4 (Zkscan4) in the hippocampi of patients with major depressive disorder and stress-susceptible mice. Zkscan4 disruption (Zkscan4-/-) was sufficient to induce depression-like behaviors following subthreshold social stress. Zkscan4 regulated excitatory synaptic transmission mainly through direct interaction with the Htr2a promoter and the recruitment of glucocorticoid receptors for the transcriptional repression of 5-hydroxytryptamine receptor 2a (Htr2a). Reduced excitatory synaptic transmission in the hippocampus and stress susceptibility in Zkscan4-/- mice were restored by pharmacological inhibition, genetic knockdown of Htr2a, or overexpression of the amino-terminal SCAN domain of Zkscan4 (Zkscan41-133) in cornus ammonis region 3. Our findings demonstrate an essential role of Zkscan4 in promoting stress resilience, suggesting a potential antidepressant effect of Zkscan41-133.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14921
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Gao, K,Yang, Y,Sun, XX,et al. Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors[J]. Sci. Adv.,2025,11(21).
APA	Gao, K.,Yang, Y.,Sun, XX.,Wang, JX.,Sun, XQ.,...&Li, J.(2025).Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors.Sci. Adv.,11(21).
MLA	Gao, K,et al."Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors".Sci. Adv. 11.21(2025).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2026070605.pdf（10868KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文