A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse

	A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse
	Chen, YX; Zhang, XP; Cooper, DN; Wu, DD; Bao, WD
	2025
发表期刊	BMC Biol.
卷号	23 期号:1
摘要	Background The post-anal tail is a common physical feature of vertebrates including mammals. Although it exhibits rich phenotypic diversity, its development has been evolutionarily conserved as early as the embryonic period. Genes participating in embryonic tail morphogenesis have hitherto been widely explored on the basis of experimental discovery, whereas the associated cis-regulatory elements (CREs) have not yet been systematically investigated for vertebrate/mammalian tail development. Results Here, utilizing high-throughput sequencing schemes pioneered in mice, we profiled the dynamic transcriptome and CREs marked by active histone modifications during embryonic tail morphogenesis. Temporal and spatial disparity analyses revealed the genes specific to tail development and their putative CREs, which facilitated the identification of novel molecular expression features and potential regulatory influence of non-coding loci including long non-coding RNA (lncRNA) genes and CREs. Moreover, these identified sets of multi-omics data supply genetic clues for understanding the regulatory effects of relevant signaling pathways (such as Fgf, Wnt) dominating embryonic tail morphogenesis. Conclusions Our work brings new insights and provides exploitable fundamental datasets for the elucidation of the complex genetic mechanisms responsible for the formation of the vertebrate/mammalian tail.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14923
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Chen, YX,Zhang, XP,Cooper, DN,et al. A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse[J]. BMC Biol.,2025,23(1).
APA	Chen, YX,Zhang, XP,Cooper, DN,Wu, DD,&Bao, WD.(2025).A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse.BMC Biol.,23(1).
MLA	Chen, YX,et al."A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse".BMC Biol. 23.1(2025).

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