Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice

	Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice
	Wang, XR; Zeng, C; Wu, ZH; Lu, MM; Wang, X; Xiu, Y; Wang, Q; Wang, SY; Chen, XY; Shen, Y; Li, H; Su, YX; Chen, PH; Chen, H; Sheng, NY; Mo, W; Yi, CJ; Yang, QW; Verkhratsky, A; Niu, JQ; Xiao, L
	2025
发表期刊	Nat. Commun.
卷号	17 期号:1
摘要	Autism spectrum disorders (ASD) are neurodevelopmental disorders associated with synaptic deficits. Oligodendrocyte precursor cells (OPCs) are the only type of glial cells that establish direct synaptic connections with neurons within the central nervous system (CNS). However, the mechanism that results in the delicate construction of OPC-neuron synaptic connections remain poorly understood. Here we show in a mouse model that BAF155, a chromatin remodeling factor, is highly expressed in committed OPCs. BAF155 influences the OPC differentiation and myelination by coordinating the expression of multiple synapse-related genes that mediate OPC-neuron synaptic communication. The varying chromatin regulatory roles of BAF155 across brain regions give rise to local myelin deficits, contributing to the diverse clinical manifestations observed in individuals with ASD. Collectively, these results deepen our insight into OPC-neuron interactions under pathophysiological conditions and uncover a mechanism that integrates synaptic and ASD susceptibility genes, implying that abnormal OPC-neuron synaptogenesis could be an early instigator of ASD.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14962
专题	科研部门_神经突触机制与功能研究组（盛能印）
推荐引用方式 GB/T 7714	Wang, XR,Zeng, C,Wu, ZH,et al. Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice[J]. Nat. Commun.,2025,17(1).
APA	Wang, XR.,Zeng, C.,Wu, ZH.,Lu, MM.,Wang, X.,...&Xiao, L.(2025).Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice.Nat. Commun.,17(1).
MLA	Wang, XR,et al."Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice".Nat. Commun. 17.1(2025).

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