Prefrontal Cortex Molecular Signatures of Chronically Socially Isolated Rats and Their Response to Fluoxetine Treatment

KIZ OpenIR > 科研部门 > 蛋白质组学平台(Christoph W. Turck )

	Prefrontal Cortex Molecular Signatures of Chronically Socially Isolated Rats and Their Response to Fluoxetine Treatment
	Filipovic, D; Turck, CW
	2025
发表期刊	Mol. Neurobiol.
ISSN	0893-7648
卷号	62 期号:11 页码:14544-14559
摘要	Despite intensive scientific and clinical research, the pathophysiological mechanisms of major depressive disorder (MDD) are still not fully understood, impeding the discovery of new effective treatments. A significant clinical challenge is the delayed onset of antidepressant efficacy, which limits timely therapeutic intervention. Recent advances in proteomics and metabolomics offer new opportunities to explore these complexities at the molecular level. This review presents a comprehensive analysis of the biochemical alterations and affected molecular pathways associated with depressive-like behavior in adult male rats subjected to chronic social isolation stress (CSIS), a well-established rodent model of depression. Additionally, it examines the effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI) commonly used in MDD treatment, to uncover potential mechanisms underlying the drug's therapeutic action. By integrating mass spectrometry-based proteomic and metabolomic analyses of cytosolic, nonsynaptic mitochondrial, and synaptosomal-enriched fractions of the rat prefrontal cortex, an area crucially implicated in both clinical and animal models of depression, this review provides insights into state-specific molecular signatures. The findings discussed here contribute to a deeper understanding of the neurobiological basis of depression and offer novel insights into the biochemical mechanisms mediating antidepressant effects, with potential for the development of improved therapeutic strategies.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15026
专题	科研部门_蛋白质组学平台(Christoph W. Turck )
推荐引用方式 GB/T 7714	Filipovic, D,Turck, CW. Prefrontal Cortex Molecular Signatures of Chronically Socially Isolated Rats and Their Response to Fluoxetine Treatment[J]. Mol. Neurobiol.,2025,62(11):14544-14559.
APA	Filipovic, D,&Turck, CW.(2025).Prefrontal Cortex Molecular Signatures of Chronically Socially Isolated Rats and Their Response to Fluoxetine Treatment.Mol. Neurobiol.,62(11),14544-14559.
MLA	Filipovic, D,et al."Prefrontal Cortex Molecular Signatures of Chronically Socially Isolated Rats and Their Response to Fluoxetine Treatment".Mol. Neurobiol. 62.11(2025):14544-14559.

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2026070604.pdf（1581KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文