Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance

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	Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance
	Peng, JY; Wang, GW; Han, YY; Qu, LL; Wang, M; Arnsten, AFT; Cai, JX; Li, BM
	2025
发表期刊	Transl. Psychiatr.
ISSN	2158-3188
卷号	15 期号:1
摘要	NR2A and NR2B are the major GluR2 subunits of N-methyl-D-aspartate (NMDA) receptor. NR2B-containing NMDA receptor was found to be exclusively expressed in post-synapses in layer III pyramidal cells of the prefrontal cortex (PFC). Many studies have suggested the importance of PFC NR2B-containing NMDA receptor for working memory, especially for the persistent delay cell firing. However, direct evidence for the necessity of PFC NR2B-containing NMDA receptor on working memory is still absent, especially in non-human primates. Here, we directly evaluated the necessity of PFC synaptic NR2B for working memory in both rats and monkeys. We first examined the synaptosome expression ratio of NR2B/2A in the PFC, hippocampus and visual cortex, and confirmed a relatively higher expression ratio of NR2B/2A in the PFC than in the hippocampus and visual cortex in both species. We then investigated the effects of intra-PFC blockade of NR2B on the performance of spatial working memory and pattern discrimination, and found that the spatial working memory, but not pattern discrimination, was robustly impaired in a delay length-dependent way in both species. The present study provided behavioral and neuropharmacological evidence for the critical role of PFC NR2B-containing receptors in working memory performance in non-human primates.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15170
专题	其他
推荐引用方式 GB/T 7714	Peng, JY,Wang, GW,Han, YY,et al. Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance[J]. Transl. Psychiatr.,2025,15(1).
APA	Peng, JY.,Wang, GW.,Han, YY.,Qu, LL.,Wang, M.,...&Li, BM.(2025).Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance.Transl. Psychiatr.,15(1).
MLA	Peng, JY,et al."Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance".Transl. Psychiatr. 15.1(2025).

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