Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development

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	Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development
	Tu, T; Cai, XL; Sun, ZP; Yang, C; Jiang, J; Wan, LLY; Ai, JQ; Wang, Y; Coulibaly, S; Tang, BS; Wang, J; Wang, JH; Zhang, Y; Wang, XP; Peng, Y; Wang, H; Pan, AH; Yan, XX; Tu, EW; Zhang, QL
	2025
发表期刊	Sci Rep
ISSN	2045-2322
卷号	15 期号:1
摘要	alpha-Smooth muscle actin (alpha SMA) is best characterized as the building block of thin filaments in smooth muscle cells. We observed a clear alpha SMA immunolabeling in adult human hippocampal mossy fibers (MF), prompting us to explore this novel pattern in phylogenic and ontogenic perspectives in the present study. alpha SMA immunolabeling occurred distinctively at the hippocampal MF terminals in humans from infancy to elderly. Hippocampal MF alpha SMA immunolabeling was not observed in mice and rats, visible in CA3 in guinea pigs and cats, and prominent in CA3 and dentate hilus in Rhesus monkeys. MF alpha SMA immunolabeling in human hippocampus emerged and refined from the last gestational trimester to early infancy. A transient overall neuronal labeling of alpha SMA was observed in prenatal human brains. alpha SMA expression was detected in human and rat primary neuronal cultures. The specificity of alpha SMA antibodies was confirmed by ACTA2 small interfering RNA (siRNA) silencing in SH-SY5Y cells. With this validation, we detected a higher alpha SMA protein level in dentate gyrus lysates relative to other human brain areas. Taken together, alpha SMA is distinctly expressed in human hippocampal mossy fibers. This pattern is related to hippocampal evolution among mammals and involves a refinement of neuronal alpha SMA expression during brain development.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15175
专题	其他
推荐引用方式 GB/T 7714	Tu, T,Cai, XL,Sun, ZP,et al. Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development[J]. Sci Rep,2025,15(1).
APA	Tu, T.,Cai, XL.,Sun, ZP.,Yang, C.,Jiang, J.,...&Zhang, QL.(2025).Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development.Sci Rep,15(1).
MLA	Tu, T,et al."Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development".Sci Rep 15.1(2025).

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2026071424.pdf（576KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文