| Contrast features of CpG islands in the promoter and other regions in the dog genome | |
| Han L1,2,3; Zhao ZM*1,4,5; zzhao@vcu.edu | |
| 2009 | |
| 发表期刊 | GENOMICS
 |
| ISSN | 0888-7543 |
| 卷号 | 94期号:2页码:117-124 |
| 合作性质 | 其它 |
| 摘要 | The recent release of the domestic dog genome provides us with an ideal opportunity to investigate dog-specific genomic features. In this study, we performed a systematic analysis of CpG islands (CGIs), which are often considered gene markers, in the dog genome. Relative to the human and mouse genomes, the dog genome has a remarkably large number of CGIs and high CGI density, which is contributed by its noncoding sequences. Surprisingly, the dog genome has fewer CGIs associated with the promoter regions of genes than the human or the mouse. Further examination of functional features of dog-human-mouse homologous genes suggests that the dog might have undergone a faster erosion rate of promoter-associated CGIs than the human or mouse. Some genetic or genomic factors such as local recombination rate and karyotype may be related to the unique clog CGI features. |
| 关键词 | Cpg Islands Dog Promoter Homologous Genes Domestication Gene Ontology Genome Evolution Essential Genes Housekeeping Genes |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | This project was supported by a NIH grant (LM009598) from the National Library of Medicine, an institutional research grant (IRG-73-001-31) from the American Cancer Society and the Thomas F. and Kate Miller Jeffress Memorial Trust research grant to Z. Zhao. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/2183 |
| 专题 | 科研部门_比较基因组学（宿兵） 遗传资源与进化国家重点实验室 |
| 通讯作者 | zzhao@vcu.edu |
| 作者单位 | 1.Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School, Chinese Academy of Sciences, Beijing 100039, China 4.Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 5.Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284, USA |
| 推荐引用方式 GB/T 7714 | Han L,Zhao ZM*,zzhao@vcu.edu. Contrast features of CpG islands in the promoter and other regions in the dog genome[J]. GENOMICS,2009,94(2):117-124. |
| APA | Han L,Zhao ZM*,&zzhao@vcu.edu.(2009).Contrast features of CpG islands in the promoter and other regions in the dog genome.GENOMICS,94(2),117-124. |
| MLA | Han L,et al."Contrast features of CpG islands in the promoter and other regions in the dog genome".GENOMICS 94.2(2009):117-124. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2009942117.pdf（598KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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