An anionic antimicrobial peptide from toad Bombina maxima

	An anionic antimicrobial peptide from toad Bombina maxima
	Lai R; Liu H; Lee WH; Zhang Y*; zhangy@mail.kiz.ac.cn
	2002
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	295 期号:4 页码:796-799
摘要	Amphibian skin is a rich resource of antimicrobial peptides like maximins and maximins H from toad Bombina maxima. A novel cDNA clone encoding a precursor protein that comprises maximin 3 and a novel peptide. named maximin H5. was isolated from a skin cDNA library of B. maxima. The predicted primary structure of maximin H5 is ILGPVLGLVSDTLDDVLGIL-NH2,. Containing three aspartate residues and no basic amino acid residues. maximin H5 is characterized by an anionic property. Different from cationic maximin H peptides. only Gram-positive strain Staphylococcus aureus was sensitive to maximin H5. while the other bacteria] and fungal strains tested ere resistant to it. The presence of metal ions. like Zn2+ and Mg2+, did not increase its antimicrobial potency. Maximin H5 represents the first example of potential anionic antimicrobial peptides from amphibians, The results provide the first evidence that. together kith cationic antimicrobial peptides. anionic antimicrobial peptides may also exist naturally as part of the innate defense system.
关键词	Anionic Antimicrobial Peptide Cationic Antimicrobial Peptide Amphibian Bombina Maxima Maximin h Cdna Clone
资助者	This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M).
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收录类别	SCI
语种	英语
资助者	This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by Grants of ‘‘STZ98-3-01’’, ‘‘Western Light Project,’’ and ‘‘Tenth Five Plan’’ pre-research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commission (2001C0061M).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2465
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_生物毒素与人类疾病（张云）
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, People’s Republic of China
推荐引用方式 GB/T 7714	Lai R,Liu H,Lee WH,et al. An anionic antimicrobial peptide from toad Bombina maxima[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2002,295(4):796-799.
APA	Lai R,Liu H,Lee WH,Zhang Y*,&zhangy@mail.kiz.ac.cn.(2002).An anionic antimicrobial peptide from toad Bombina maxima.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,295(4),796-799.
MLA	Lai R,et al."An anionic antimicrobial peptide from toad Bombina maxima".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295.4(2002):796-799.

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