| Molecular basis of albinism in the rhesus monkey | |
Ding B1; Ryder OA2; Wang XX1; Bai SC1; Zhou SQ1; Zhang YP*1
| |
| 2000 | |
| 发表期刊 | MUTATION RESEARCH
 |
| ISSN | 0027-5107 |
| 卷号 | 449期号:1-2页码:1-6 |
| 合作性质 | 其它 |
| 摘要 | Sequence analysis of the tyrosinase (TYR) coding region from one albino rhesus monkey (Macaca mulatta) family revealed that the two monkeys with phenotype similar to human TYR-negative oculocutaneous albinism (OCA) were homozygous for a missense mutation (S184TER) in exon 1 at codon 184. The offspring of one of the albino monkey (''Kangkang'') are all heterozygous for the S184TER mutation, but the S184TER mutation was not observed in 93 control individuals. We conclude that the point mutation is responsible and sufficient to generate the albino rhesus monkey phenotype. The rough age of the S184TER nonsense mutation may be about 0.8 million years using a rate of 0.16% per million years. |
| 关键词 | Rhesus Monkey Oculocutaneous Albinism Tyrosinase Mutation |
| 资助者 | This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. ; This work was supported by the NSFC, Nature Science Foundation of Yunnan province, and Chinese Academy of Sci- ences. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/3987 |
| 专题 | 科研部门_分子进化与基因组多样性（张亚平） 细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Zoological Society of San Diego, San Diego, CA 92112, USA |
| 推荐引用方式 GB/T 7714 | Ding B,Ryder OA,Wang XX,et al. Molecular basis of albinism in the rhesus monkey[J]. MUTATION RESEARCH,2000,449(1-2):1-6. |
| APA | Ding B,Ryder OA,Wang XX,Bai SC,Zhou SQ,&Zhang YP*.(2000).Molecular basis of albinism in the rhesus monkey.MUTATION RESEARCH,449(1-2),1-6. |
| MLA | Ding B,et al."Molecular basis of albinism in the rhesus monkey".MUTATION RESEARCH 449.1-2(2000):1-6. |
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