分子进化与基因组多样性（张亚平）知识库

The 9-bp deletion in the COII/tRNA(Lys) intergenic region (region V) of human mitochondrial DNA was screened in 1521 Chinese from 16 ethnic groups and 9 Hen geographic groups. The highest frequency was found in populations of Miao (32.4%) and Bouyei (30.8%) from Guizhou Province, whereas no deletion was found in Kazak population in Xinjiang. In the populations of Wa and Lahu from Yunnan Province, Uygur and Mongolian from Xinjiang, the deletion frequency was relatively low(less than or equal to4%), while in the remaining 18 groups, the frequency was moderate (6% similar to 24%). Except those Hens in Xinjiang, Guizhou and that reported in Taiwan, the deletion frequency in the Hen geographic groups did not show a substantial difference. However, the deletion frequency in some ethnic groups from the same geographic region or with similar ethnohistory did not show similarity. A general decrease tendency in the deletion frequency was found from south to north and from coastal to inland. The frequency of the 9-bp deletion was approximately 17.20% in all Chinese we studied and reported elsewhere. Additionally, 4 individuals were found to carry the triplication of 9-bp segment in region V; one individual had X.II type of 9-bp deletion; and no other length polymorphisms were detected in this region in 27 randomly selected individuals with or without the deletion.