| Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population | |
Xie L1,2,3; Gong YY1,3; Lian SG4; Yang J4; Yang Y5; Gao SJ6; Xu LY6; Zhang YP*1,2
| |
| 2008 | |
| 发表期刊 | EXPERIMENTAL GERONTOLOGY
 |
| ISSN | 0531-5565 |
| 卷号 | 43期号:10页码:962-965 |
| 合作性质 | 其它 |
| 摘要 | Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential role of the promoter region variation of IGF-1 gene in longevity, we investigated 485 longevity subjects and 392 younger individuals from Dujiangyan, China. By sequencing about 2.5 kb (kilo base pairs) upstream the transcription start site of exon 1 of the IGF-1 gene in 30 individuals from both groups respectively, we acquired three previously described SNPs (-439T/A (rs2288377), -541T/C (rs5742612) and -1246C/T (rs35767)). We examined the association between these three SNPs and longevity by comparing the distribution of genotypes, alleles, and haplotypes in both the longevity and control groups. None of these variants were found to be associated with longevity. Our results suggest that there is no association between SNPs in the promoter region of IGF-1 gene and longevity in the Han Chinese population. |
| 关键词 | Longevity Igf-1 Association Study Snps Han Chinese Population |
| 资助者 | This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. ; This work was supported by National Basic Research Program of China (No. 2007CB507405), ‘‘Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), Bureau of Science and Technology of Yunnan Province. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4271 |
| 专题 | 科研部门_分子进化与基因组多样性（张亚平） 科研部门_动物模型与人类重大疾病机理重点实验室 遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming 650091, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China 4.People’s Hospital of Dujiangyan City, Dujiangyan 611830, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms and Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 6.Dujiangyan Longevity Research Centre, Dujiangyan 611830, China |
| 推荐引用方式 GB/T 7714 | Xie L,Gong YY,Lian SG,et al. Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population[J]. EXPERIMENTAL GERONTOLOGY,2008,43(10):962-965. |
| APA | Xie L.,Gong YY.,Lian SG.,Yang J.,Yang Y.,...&Zhang YP*.(2008).Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.EXPERIMENTAL GERONTOLOGY,43(10),962-965. |
| MLA | Xie L,et al."Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population".EXPERIMENTAL GERONTOLOGY 43.10(2008):962-965. |
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