Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community

	Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community
	Ma SL 1; Tang NLS 1,2,5; Tam CWC 3; Lui VWC 3; Lau ESS 1; Zhang YP4,5 ; Chiu HFK 3; Lam LCW*3
	2009
发表期刊	INTERNATIONAL PSYCHOGERIATRICS
ISSN	1041-6102
卷号	21 期号:5 页码:977-986
合作性质	其它
摘要	Background: Alzheimer's disease (AD) is a neurodegenerative disease with a higher prevalence in women. Expression of estrogen receptor 1 (ESR1) gene has been identified throughout the brain. Owing to the putative neuroprotective effects of estrogen, estrogen receptor gene is a potential candidate modulating the development of AD. Preliminary associations between two polymorphisms of ESR1 (PvuII and XbaI) gene and AD have been reported. Methods: In this study, 16 single nucleotide polymorphisms (SNPs) of the ESR1 gene (including four commonly studied ESR1 SNPs and 12 other tagging SNPs selected from the HapMap database) were investigated to further evaluate the association between ESR1 polymorphisms and the risk of AD in the Chinese population. Results: A total of 233 Chinese AD patients and 245 age-matched elderly control subjects were recruited. Genetic associations were analyzed by chi-square test and interaction effect was analysed by logistic regression analysis. Five SNPs (clustered between intron 3 and intron 7) were associated with the risk of AD (p-value ranges from 0.001 to 0.035). another two SNPs (located on exon 2 and intron 2) were shown to modulate the age-at-onset (AAO) in AD (p-value = 0.036 and 0.011). Conclusions: ESR1 gene polymorphisms may be associated with the AAO in AD. The present results provided information for possible associations between certain polymorphisms of ESR1 gene and the risk of AD.
关键词	Alzheimer's Disease Polymorphism Estrogen Receptor Chinese
资助者	This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund.
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收录类别	SCI
语种	英语
资助者	This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund. ; This work is supported by RGC Research Grant Direct Allocation from the Chinese University of Hong Kong (CRE-2003.1.072), CUHK Direct Grant and from the Mr. Lai Seung Hung and Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4341
专题	科研部门_分子进化与基因组多样性（张亚平）细胞与分子进化开放实验室
作者单位	1.Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China 2.Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China 3.Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China 4.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, P.R. China 5.Joint Laboratory of Bioresources and Molecular Research in Common Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
推荐引用方式 GB/T 7714	Ma SL,Tang NLS,Tam CWC,et al. Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community[J]. INTERNATIONAL PSYCHOGERIATRICS,2009,21(5):977-986.
APA	Ma SL.,Tang NLS.,Tam CWC.,Lui VWC.,Lau ESS.,...&Lam LCW*.(2009).Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community.INTERNATIONAL PSYCHOGERIATRICS,21(5),977-986.
MLA	Ma SL,et al."Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community".INTERNATIONAL PSYCHOGERIATRICS 21.5(2009):977-986.

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