Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus

	Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
	Wang Q 1,3; Ding ZH 2; Liu JK 2; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2004
发表期刊	ANTIVIRAL RESEARCH
ISSN	0166-3542
卷号	64 期号:3 页码:189-194
合作性质	其它
摘要	Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC 50 values were 0.82, 1.28 and 0.50?g/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC 50 value of 20.74?g/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified.
关键词	Xanthohumol Anti-hiv-1 Reverse Transcriptase Hiv Entry
资助者	The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142).
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收录类别	SCI
语种	英语
资助者	The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4529
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 3.The Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Wang Q,Ding ZH,Liu JK,et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus[J]. ANTIVIRAL RESEARCH,2004,64(3):189-194.
APA	Wang Q,Ding ZH,Liu JK,Zheng YT*,&zhengyt@mail.kiz.ac.cn.(2004).Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.ANTIVIRAL RESEARCH,64(3),189-194.
MLA	Wang Q,et al."Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus".ANTIVIRAL RESEARCH 64.3(2004):189-194.

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