Zinc coupling potentiates anti-HIV-1 activity of baicalin

	Zinc coupling potentiates anti-HIV-1 activity of baicalin
	Wang Q 1,3; Wang YT 2; Pu SP 2; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2004
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	324 期号:2 页码:605-610
合作性质	其它
摘要	Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher anti-HIV-1 activity compared with those of BA in vitro. The CC50s of BA-Zn and BA were 221.52 and 101.73 microM, respectively. The cytotoxicity of BA-Zn was about 1.2-fold lower than that of BA. The BA and BA-Zn inhibited HIV-1 induced syncytium formation, HIV-1 p24 antigen and HIV-1 RT production. The EC50s of BA-Zn on inhibiting HIV-1 induced syncytium formation (29.08 microM) and RT production (31.17 microM) were lower than those of BA (43.27 and 47.34 microM, respectively). BA-Zn was more effective than BA in inhibiting the activities of recombinant RT and HIV-1 entry into host cells. Zinc coupling enhanced the anti-HIV-1 activity of baicalin.
关键词	Baicalin Hiv-1 Rt Hiv Entry Anti-hiv Activity
资助者	The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142).
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收录类别	SCI
语种	英语
资助者	The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4531
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 2.Kunming Institute of Precious Metals, Kunming 650221, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
推荐引用方式 GB/T 7714	Wang Q,Wang YT,Pu SP,et al. Zinc coupling potentiates anti-HIV-1 activity of baicalin[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,324(2):605-610.
APA	Wang Q,Wang YT,Pu SP,Zheng YT*,&zhengyt@mail.kiz.ac.cn.(2004).Zinc coupling potentiates anti-HIV-1 activity of baicalin.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,324(2),605-610.
MLA	Wang Q,et al."Zinc coupling potentiates anti-HIV-1 activity of baicalin".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324.2(2004):605-610.

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