Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents

	Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents
	Tang JG 1,3; Wang YH 2,3; Wang RR 2,3; Dong ZJ 1; Yang LM 2; Zheng YT2; Liu JK1; jkliu@mail.kib.ac.cn
	2008
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	5 期号:3 页码:447-460
合作性质	其它
摘要	Flazin isolated from the fruiting bodies of Suillus granulatus was found to possess weak anti-HIV activity (EC50=2.36 mu m, TI= 12.1). To establish a SAR study, 46 flazin analogues were synthesized, and their anti-HIV activities were evaluated in vitro. Among them, flazinamide (9a) showed the most potent activity with an EC50 value of 0.38 pm and a TI value of 312.0. The results suggested that appropriate substituents at positions 3, 1', and 5' of flazin might play a crucial role in determining their anti-HIV activities, and that flazinamide can be considered as a promising, readily available anti-HIV agent.
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4647
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	jkliu@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China 2.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P. R. China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China
推荐引用方式 GB/T 7714	Tang JG,Wang YH,Wang RR,et al. Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents[J]. CHEMISTRY & BIODIVERSITY,2008,5(3):447-460.
APA	Tang JG.,Wang YH.,Wang RR.,Dong ZJ.,Yang LM.,...&jkliu@mail.kib.ac.cn.(2008).Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents.CHEMISTRY & BIODIVERSITY,5(3),447-460.
MLA	Tang JG,et al."Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents".CHEMISTRY & BIODIVERSITY 5.3(2008):447-460.

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