| Identification and molecular evolution of cow CENP-A gene family | |
| Li Y1; Huang JF*1,2; huangjf@mail.kiz.ac.cn | |
| 2008 | |
| 发表期刊 | MAMMALIAN GENOME
 |
| ISSN | 0938-8990 |
| 卷号 | 19期号:2页码:139-143 |
| 合作性质 | 其它 |
| 摘要 | The centromere protein A (CENP-A), a histone H3-like protein, provides an essential role for chromosomal segregation during mitosis and meiosis. In this study we identified ten new CENP-A-like genes (excluding the original CENP-A gene) in cow by searching its genome database, while all other examined mammals contained only a single copy of the CENP-A gene. Phylogenetic analysis shows that the expansion of these genes occurred before the divergence of cow and sheep but after the artiodactyls diverged from other mammals. Our analyses also indicate that multiple gene duplication and intron loss events have occurred during the formation of this gene family, and the high similarity in intron sequences between the new genes and the old one suggests very recent gene expansion events. Furthermore, evidence from the comparisons of the synonymous and nonsynonymous substitutions and the distributions of the mutation sites suggested that the CENP-A-L-1 gene, a potentially functional member of cow CENP-A gene family, evolved under positive selection. |
| 资助者 | This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. ; This work was supported by the National Nat- ural Science Foundation of China (NSFC) (Grant No. 30600066) and the ‘‘Light in Western China’’ of the Chinese Academy of Sciences for YL, and the NSFC (Grant Nos. 30021004, 30470939, 30024004, and 30623007) for JFH. The authors thank Mr. Nelson Ting from the City University of New York and Jing Luo from the Yunnan Uni- versity for editing the manuscript. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4905 |
| 专题 | 结构生物信息学 细胞与分子进化开放实验室 |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Peoples Republic of China 2.Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming 650223, Peoples Republic of China |
| 推荐引用方式 GB/T 7714 | Li Y,Huang JF*,huangjf@mail.kiz.ac.cn. Identification and molecular evolution of cow CENP-A gene family[J]. MAMMALIAN GENOME,2008,19(2):139-143. |
| APA | Li Y,Huang JF*,&huangjf@mail.kiz.ac.cn.(2008).Identification and molecular evolution of cow CENP-A gene family.MAMMALIAN GENOME,19(2),139-143. |
| MLA | Li Y,et al."Identification and molecular evolution of cow CENP-A gene family".MAMMALIAN GENOME 19.2(2008):139-143. |
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| 200819139.pdf（180KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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