Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine

KIZ OpenIR > 其他

	Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine
	Arnsten AFT 1; Cai JX 2
	1993
发表期刊	NEUROBIOLOGY OF AGING
ISSN	0197-4580
卷号	14 期号:6 页码:597-603
合作性质	其它
摘要	Very low doses (0.00001 mg/kg) of the alpha-2 adrenergic antagonist, yohimbine, improved working memory performance in a subset of aged monkeys. Improvement appeared to result from increased norepinephrine (NE) release onto postsynaptic alpha-2 adrenoceptors, as the response was blocked by the ''postsynaptic'' alpha-2 antagonist, SKF104078. Cognitive-enhancing effects of low dose yohimbine treatment may depend on aged animals retaining an intact, endogenous NE system. In contrast to yohimbine, the alpha-2 agonist, clonidine, has improved working memory in air aged animals examined. In the present study, clonidine's beneficial effects were also blocked by the postsynaptic antagonists SKF104078 and SKF104856, suggesting that clonidine acts by directly stimulating postsynaptic alpha-2 adrenoceptors. Beneficial doses of clonidine (0.01 mg/kg) and yohimbine (0.00001 mg/kg) were combined to see if they would produce additive effects on memory enhancement. This strategy was successful in young monkeys with intact NE systems but was not effective in the aged monkeys. These findings demonstrate that drugs that indirectly stimulate postsynaptic alpha-2 receptors by increasing NE release are not as reliable in aged monkeys as directly acting agonists that can replace NE at postsynaptic alpha-2 receptors.
关键词	Skf104856 Skf104078 Prefrontal Cortex Aging Primates Norepinephrine Alpha-2 Adrenoceptors Delayed Response Task
URL	查看原文
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5055
专题	其他
作者单位	1.Section of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510-8001, USA 2.Kunming Institute of Zoology, Academia Sinica, Kunming, Yunnan, China 650223
推荐引用方式 GB/T 7714	Arnsten AFT,Cai JX. Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine[J]. NEUROBIOLOGY OF AGING,1993,14(6):597-603.
APA	Arnsten AFT,&Cai JX.(1993).Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine.NEUROBIOLOGY OF AGING,14(6),597-603.
MLA	Arnsten AFT,et al."Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine".NEUROBIOLOGY OF AGING 14.6(1993):597-603.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
199314597.pdf（560KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文