Comparative studies on parallel and antiparallel duplex and triplex DNA

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	Comparative studies on parallel and antiparallel duplex and triplex DNA
	Liu CQ 1,2; Shi XF 1,2; Bai CL 3; Zhao JS 1; Wang Y 1,2
	1997
发表期刊	JOURNAL OF THEORETICAL BIOLOGY
ISSN	0022-5193
卷号	184 期号:3 页码:319-325
摘要	Parallel strand models for base sequences d(A)10.d(T)10,d(AT)5.d(TA)5, d(G5C5).d(C5G5), d(GC)5.d(CG)5 and d(CTATAGGGAT).d(GATATCCCTA), where reverse Watson-Crick A-T pairing with two H-bonds and reverse Watson-Crick G-C pairing with one H-bond or with two H-bonds were adopted, and three models of d(T)14.d(A)14.d(T)14 triple helix with different strand orientations were built up by molecular architecture and energy minimization. Comparisons of parallel duplex models with their corresponding B-DNA models and comparisons among the three triple helices showed: (i) conformational energies of parallel AT duplex models were a little lower, while for GC duplex models they were about 8% higher than that of their corresponding B-DNA models; (ii) the energy differences between parallel and B-type duplex models and among the three triple helices arose mainly from base stacking energies, especially for GC base pairing; (iii) the parallel duplexes with one H-bond G-C pairs were less stable than those with two H-bonds G-C pairs. The present paper includes a brief discussion about the effect of base stacking and base sequences on DNA conformations.
资助者	This project was supported by the ‘‘8.5’’ Great and Important Project of the Chinese Academy of Sciences and National Natural Science Foundation of China. ; This project was supported by the ‘‘8.5’’ Great and Important Project of the Chinese Academy of Sciences and National Natural Science Foundation of China.
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收录类别	SCI
语种	英语
资助者	This project was supported by the ‘‘8.5’’ Great and Important Project of the Chinese Academy of Sciences and National Natural Science Foundation of China. ; This project was supported by the ‘‘8.5’’ Great and Important Project of the Chinese Academy of Sciences and National Natural Science Foundation of China.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5131
专题	其他细胞与分子进化开放实验室
作者单位	1.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 65022 2.Modern Biological Center, Yunnan University, Kunming 650091 3.Laboratory of STM, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China
推荐引用方式 GB/T 7714	Liu CQ,Shi XF,Bai CL,et al. Comparative studies on parallel and antiparallel duplex and triplex DNA[J]. JOURNAL OF THEORETICAL BIOLOGY,1997,184(3):319-325.
APA	Liu CQ,Shi XF,Bai CL,Zhao JS,&Wang Y.(1997).Comparative studies on parallel and antiparallel duplex and triplex DNA.JOURNAL OF THEORETICAL BIOLOGY,184(3),319-325.
MLA	Liu CQ,et al."Comparative studies on parallel and antiparallel duplex and triplex DNA".JOURNAL OF THEORETICAL BIOLOGY 184.3(1997):319-325.

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