Interaction between human interleukin-16 and CD4 receptor of HIV-1

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	Interaction between human interleukin-16 and CD4 receptor of HIV-1
其他题名	人白介素16与HIV-1的CD4受体的相互作用
	Yang J 1; Liu CQ*1,2; tbrg@public.km.yn.cn
	2000
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	0253-9756
卷号	21 期号:6 页码:547-553
合作性质	其它
摘要	AIM: To study the interaction between human interleukin-16 (IL-16) and the receptor CD4 (T-lymphocyte differentiation antigen) of human immunodeficiency virus type 1 (HIV-1). METHODS: Two structurally con served regions (SCRs) of human IL-16 were built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of human interleukin-1 (HIL-4) and HIL-2 as the templates. The coordinates for amino-terminal residue sequence, carboxyl-terminal residue sequences, and cytoplasm loops were generated using Biopolymer's LOOP SEARCH algorithm. RESULTS: HIL-16 first formed a homodimer, then contacted with CD4 dimer further forming a dimeric complex. Subsequently, the dimeric complex constructed the tetrameric complex by two disulfide bridges between the cysteines of HIL-16 (Cys31-Cys31). CONCLUSION: The interaction model is useful to propose the action mechanism of HIL-16 and is beneficial for rational designing of novel anti-HIV drugs.
其他摘要	目的:研究人白介素-16和HIV-1病毒受体CD4(T淋巴细胞分化抗原)的作用机理。方法:人白介素-16的结构保守区由SYBYL软件中的Biopolymer模块建立,其非保守区由LOOP SEARCH方法建立。结果:人白介素-16首先形成二聚体,然后与CD4的二聚体进一步形成HIL-16与CD4的复合物二聚体。接着,该复合物二聚体通过二硫键(Cys31-Cys31)形成HIL-16与CD4复合物的四聚体。结论:该相互作用模型有助于推测白介素-16的作用机制,也有益于全新抗艾滋病药物的合理设计。
关键词	Molecular Structure Interleukin-16 Cd4 Antigens Computer-aided Design Protein Conformation
资助者	Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418
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收录类别	其他
语种	英语
资助者	Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418 ; Project supported by the National Natural Science Foundation of China, № 39770418
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5167
专题	其他细胞与分子进化开放实验室
通讯作者	tbrg@public.km.yn.cn
作者单位	1.CAS, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming 650223, Peoples R China 2.Yunnan Univ, Mod Biol Ctr, Kunming 650091, Peoples R China
推荐引用方式 GB/T 7714	Yang J,Liu CQ*,tbrg@public.km.yn.cn. Interaction between human interleukin-16 and CD4 receptor of HIV-1[J]. ACTA PHARMACOLOGICA SINICA,2000,21(6):547-553.
APA	Yang J,Liu CQ*,&tbrg@public.km.yn.cn.(2000).Interaction between human interleukin-16 and CD4 receptor of HIV-1.ACTA PHARMACOLOGICA SINICA,21(6),547-553.
MLA	Yang J,et al."Interaction between human interleukin-16 and CD4 receptor of HIV-1".ACTA PHARMACOLOGICA SINICA 21.6(2000):547-553.

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