Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study

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	Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study
	Yu SM 1,2,3; Cai JX*1,2; caijx@mail.kiz.ac.cn
	2003
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	339 期号:3 页码:187-190
合作性质	其它
摘要	The effects of aniracetam on extracellular amino acid levels in the hippocampus of conscious gerbils, with or without transient cerebral ischemia/reperfusion, were measured by microdialysis and reverse phase-high performance liquid chromatography. Increased extracellular levels of aspartate and glutamate that were observed in the hippocampus of conscious gerbils during transient global forebrain ischemia were reversed by aniracetam. In contrast, the level of extracellular gamma-aminobutyric acid was increased, while taurine was maintained at a higher level than other amino acids by administration of aniracetam (100 mg/kg, p.o.) 60 min before ischemia. Further, in contrast to ischemic animals, administration of aniracetam (100 mg/kg, p.o.) enhanced the release of glutamate and aspartate in the normal gerbil hippocampus. The results suggest that these effects might be due to a partial calcium agonist activity of aniracetam, and that the effects of aniracetam on amino acid levels might be a mechanism of protection against delayed neuronal death in the ischemic hippocampus, thereby improving memory dysfunction induced by ischemia/reperfusion.
关键词	Aniracetam Transient Cerebral Ischemia Hippocampus Microdialysis Reverse Phase-high Performance Liquid Chromatography Amino Acid Transmitters Gerbil
资助者	The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z
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收录类别	SCI
语种	英语
资助者	The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z ; The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5285
专题	其他
通讯作者	caijx@mail.kiz.ac.cn
作者单位	1.Section of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Graduate school of the Chinese Academy of Sciences, Beijing 100039, PR China 3.College of Life Sciences, Anhui University, Hefei 230039, PR China
推荐引用方式 GB/T 7714	Yu SM,Cai JX*,caijx@mail.kiz.ac.cn. Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study[J]. NEUROSCIENCE LETTERS,2003,339(3):187-190.
APA	Yu SM,Cai JX*,&caijx@mail.kiz.ac.cn.(2003).Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study.NEUROSCIENCE LETTERS,339(3),187-190.
MLA	Yu SM,et al."Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study".NEUROSCIENCE LETTERS 339.3(2003):187-190.

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