Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes

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	Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes
	Chen BY*1,5; Cai JX 1; Song LS 2; Wang XQ 3; Chen ZH 4; bichen@iupui.edu
	2005
发表期刊	LIFE SCIENCES
ISSN	0024-3205
卷号	76 期号:10 页码:1111-1121
摘要	Ginkgo biloba extract (GBE), a valuable natural product for cerebral and cardiovascular diseases, is mainly composed of two classes of constituents: terpene lactones (e.g., ginkgolide A and B, bilobalide) and flavone glycosides (e.g., quercetin and kaempferol). Its electrophysiological action in heart is yet unclear. In the present study, using whole-cell patch clamp technique, we investigated electrophysiological effects of GBE on cation channel currents in ventricular myocytes isolated from rat hearts. We found that GBE 0.01-0.1% inhibited significantly the sodium current (I(Na)), L-type calcium current (I(Ca)) and transient outward potassium current (IK(to)) in a concentration-dependent manner. Surprisingly, its main ingredients, ginkgolide A (GB A), ginkgolide B (GB B) and bilobalide (GB BA) at 0.1 mM did not exhibit any significant effect on these cation channel currents. These results suggested that GBE is a potent non-selective cation channel modulator in cardiaomyocytes. Other constituents (rather than GB A, GB B and GB BA) might be responsible for the observed inhibitory effects of GBE on cation channels.
关键词	Ginkgo Biloba Extract Sodium Channel Current Potassium Channel Current Calcium Channel Current Ventricular Myocytes
资助者	This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M).
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收录类别	SCI
语种	英语
资助者	This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). ; This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5351
专题	其他
通讯作者	bichen@iupui.edu
作者单位	1.Section of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD, USA 3.Department of Physiology, Kunming Medical College, Kunming, China 4.Yunnan Province Key Laboratory of Pharmacology for Natural Products, Kunming Medical College, Kunming, China 5.Division of Gastroentology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
推荐引用方式 GB/T 7714	Chen BY*,Cai JX,Song LS,et al. Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes[J]. LIFE SCIENCES,2005,76(10):1111-1121.
APA	Chen BY*,Cai JX,Song LS,Wang XQ,Chen ZH,&bichen@iupui.edu.(2005).Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.LIFE SCIENCES,76(10),1111-1121.
MLA	Chen BY*,et al."Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes".LIFE SCIENCES 76.10(2005):1111-1121.

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