| GABA and its agonists improved visual cortical function in senescent monkeys | |
| Leventhal AG*1; Wang YC1; Pu ML1; Zhou YF2; Ma YY3; audie.leventhal@m.cc.utah.edu | |
| 2003 | |
| 发表期刊 | SCIENCE
 |
| ISSN | 0036-8075 |
| 卷号 | 300期号:5620页码:812-815 |
| 合作性质 | 其它 |
| 摘要 | Human cerebral cortical function degrades during old age. Much of this change may result from a degradation of intracortical inhibition during senescence. We used multibarreled microelectrodes to study the effects of electrophoretic application of gamma-aminobutyric acid (GABA), the GABA type a (GABAa) receptor agonist muscimol, and the GABAa receptor antagonist bicuculline, respectively, on the properties of individual V1 cells in old monkeys. Bicuculline exerted a much weaker effect on neuronal responses in old than in young animals, confirming a degradation of GABA-mediated inhibition. On the other hand, the administration of GABA and muscimol resulted in improved visual function. Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/5423 |
| 专题 | 认知障碍病理学 |
| 通讯作者 | audie.leventhal@m.cc.utah.edu |
| 作者单位 | 1.Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA 2.School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China 3.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kun- ming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Leventhal AG*,Wang YC,Pu ML,et al. GABA and its agonists improved visual cortical function in senescent monkeys[J]. SCIENCE,2003,300(5620):812-815. |
| APA | Leventhal AG*,Wang YC,Pu ML,Zhou YF,Ma YY,&audie.leventhal@m.cc.utah.edu.(2003).GABA and its agonists improved visual cortical function in senescent monkeys.SCIENCE,300(5620),812-815. |
| MLA | Leventhal AG*,et al."GABA and its agonists improved visual cortical function in senescent monkeys".SCIENCE 300.5620(2003):812-815. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2003300812.pdf（307KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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